Recommended use: Two a day
60 capsules 40,000 IU each.
Retail $24.95 - ET Price $20.00
The following is extracted from "The 2nd Gift from Silkworm is Serrapeptase" for educational purposes.
The digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms. The late German physician, Dr.
Hans Nieper, used Serrapeptase to treat arterial blockage in his coronary patients. Serrapeptase protects against stroke and is
reportedly more effective and quicker than EDTA Chelation treatments in removing arterial plaque. He also reports that
Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish. Dr. Nieper told of a woman scheduled for hand
amputation and a man scheduled for bypass surgery who both recovered quickly without surgery after treatment with
SerraEzyme (Serrapeptase) has wide clinical use spanning over twenty-five years throughout Europe and Asia as a viable
alternative to salicylates, ibuprofen and the more potent NSAIDs. Unlike these drugs, SerraEzyme is a naturally occurring,
physiologic agent with no inhibitory effects on prostaglandins and is devoid of gastrointestinal side effects.
SerraEzyme is a proteolytic enzyme isolated from the micro-organism, Serratia E15. This enzyme is naturally present in the
silkworm intestine and is processed commercially today through fermentation. This immunologically active enzyme is completely
bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally
Indications shown in various studies and reported by Practitioners on their patients:
Pain of any kind.
Arthritis, MS, (Multiple Sclerosis), Rheumatoid Arthritis and Lupus etc.
Headaches and Migraines caused by inflammation.
Lungs - Emphysema, Bronchitis, Pulmonary Tuberculosis, Bronchial Asthma, Bronchiectasis etc
Eye Problems from inflammation or blocked veins etc.
Sinusitis problems, chronic ear infections and runny nose etc
Sports Injuries, traumatic swelling, post operative swellings and leg ulcers that are not healing.
Inflammation of any kind: inflammatory bowels diseases-, (Crohn’s, Colitis etc) Cystitis etc and in joints or muscles e.g.
Breast Engorgement, Fibrocystic Breast Disease etc
Cardiovascular Disease and Varicose Veins etc
The main question we are asked is:
Will this conflict with any drugs I am taking or cause my blood to become to thin?”
There are many opinions about what to take with what and what is a so called 'blood thinner'.
First, Aspirin is NOT a blood thinner such as Warfarin. Aspirin is an anti-inflammatory as are all proteolytic enzymes. They cause
the blood to flow normally, not thinner than normal by stopping the inflammation in the blood stream that causes blood clotting.
The prime cause of western diseases is now considered to be chronic inflammation caused by eating starchy carbohydrates,
processed, micro-waved and generally overcooked foods. This is measured by the rise in C-Reactive proteins after eating such
foods. When we have chronic inflammation as well as free radical damage, we get what is known as sticky blood, where the
platelets stick together and can clot.
Any method of anti-inflammatory action would cause the blood to thin when the blood cells stop being sticky.
Even just eating salad or raw vegetables would cause the same action as Aspirin or Warfarin. I have yet to see Doctors telling
people not to eat too much salad when they are taking Warfarin (but who knows what they may say next?).
It could even be taken even if you had nothing wrong whatsoever (inflammation also being the cause of premature ageing).
A Potent Proteolytic Enzyme
The inflammatory response is an important mechanism for protecting the body from attack by invading organisms and faulty cells. In the case of
immune dis-regulation, the body loses its ability to differentiate between innocuous and potentially dangerous substances. This defective
mechanisms results in a wide array of autoimmune diseases such as allergies, psoriasis, rheumatoid arthritis, ulcerative colitis, uveitis, multiple
sclerosis and some forms of cancer.
Standard drug therapy for inflammatory-mediated diseases and trauma include steroids and non-steroidal anti-inflammatory agents (NSAIDs). Both
classes of drugs offer temporary, symptomatic relief from swelling, inflammation and accompanying pain without treating the underlying condition.
These drugs may also be immunosuppressive and cause dangerous side effects. The conscientious physician must weigh the benefits and
long-term risks associated with the use of NSAIDs, especially in cases of rheumatoid arthritis. If left untreated, the inflammatory process itself can
lead to limitation of joint function and destruction of bone, cartilage and articular structures.
NSAIDs are among the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. Their effects are mediated
through inhibition of the biosynthesis of prostaglandins. They work by irreversibly blocking cyclooxygenase, the enzyme which catalyses the
reactions of arachidonic acid to endoperoxide compounds. The neurological and gastrointestinal side effects of these agents have been reviewed in
considerable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosai
cytoprotection. A common side effect from these medications is gastric ulcers. More serious adverse reactions such as blood dyscrasias, kidney
damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one
causes side effects or stops working.
The search for a physiologic agent that offers anti-inflammatory properties without causing side effects may have ended with the discovery of the
Serratia peptidase (SP) enzyme. This anti-inflammatory agent is in wide clinical use throughout Europe and Asia as a viable alternative to
salicylates, ibuprofen (sold as an OTC in the U.S.) and the more potent NSAIDs. Unlike these drugs, SP is a naturally occurring, physiologic
agent with no inhibitory effects on prostaglandins and devoid of gastrointestinal side effects.
SP is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia El5. This enzyme is naturally present in the silkworm
intestine and is processed commercially today through fermentation. This immunologically active enzyme is completely bound to the alpha 2
macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme.
The silkworm has a symbiotic relationship with the Serratia microorganisms in its intestines. The enzymes secreted by the bacteria in silkworm
intestines have a specific affinity to avital tissue and have no detrimental effect on the host's living cells. By dissolving a small hole in the ~
silkworm's protective cocoon (avital tissue), the winged creature is able to emerge and fly away. The discovery of this unique biological
phenomenon led researchers to study clinical applications of the SP enzyme in man. In addition to its widespread use in arthritis, fibrocystic
breast disease and carpal tunnel syndrome, researchers in Germany have used SP for atherosclerosis. SP helps to digest atherosclerotic plaque
without harming the healthy cells lining Z the arterial wall. Today, researchers consider atherosclerosis an inflammatory condition similar to other
degenerative diseases. Some immunologists are even categorizing atherosclerosis as a benign tumour. Hardening and narrowing of the arterial
wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidized lipids. SP doesn't interfere with the synthesis of
cholesterol in the body, but helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant
and a necessary component of the major organ systems in the body. The use of medications, which block cholesterol biosynthesis, may
eventually damage the liver and compromise anti-oxidant status of the eyes, lungs and other soft tissues.
While studies with SP in the treatment of coronary artery disease are relatively new, a wealth of information exists regarding its anti-inflammatory
properties. SP has been used as an anti-inflammatory agent in the treatment of chronic sinusitis, to improve the elimination of bronchopulmonary
secretions, traumatic injury (e.g. sprains and torn ligaments), post-operative inflammation and to facilitate the therapeutic effect of antibiotics in the
treatment of infections. In the urological field, SP has been used successfully for cystitis and epididymitis.
SP has been admitted as a standard treatment Germany and other European countries for the treatment of inflammatory and traumatic swellings.
In one double-blind study of SP conducted by Esch et al at the German State Hospital in UIm, 66 patients with fresh rupture of the lateral ligament
treated surgically were divided in three randomised groups. In the group receiving the test substance, the swelling had decreased by 50% on the
third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with or without the application of ice), no reduction in
swelling had occurred at that time. The difference was of major statistical significance. Decreasing pain correlated for the most part with the
reduction in swelling. The patients receiving SP became pain-free more rapidly than the control groups. By the 10th day, all patients were free of
pain in the SP-treated group. The therapeutic daily dose was 1-2 tablets (5 mg) 3 times daily. In another double-blind study, the anti-inflammatory
enzyme, SP, was evaluated in a group of 70 patients with evidence of cystic breast disease. These patients were randomly divided into a
treatment group and a placebo group. SP was noted to be superior to placebo for improvement of breast pain, breast swelling and induration with
85.7% of the patients receiving SP reporting moderate to marked improvement. No adverse reactions were reported with the use of SP. The use of
enzymes with fibrinolytic, proteolytic and anti-edemic activities for the treatment of inflammatory conditions of the ear, nose and throat has gained
increasing support in recent years.
In a third double-blind study, 193 subjects suffering from acute or chronic ear, nose or throat disorders were evaluated. Treatment with SP lasted
7-8 days, two 5 mg tabs, t.i.d. After 3-4 days treatment, significant symptom regression was observed in the SP-treated group, while this was not
noted in the control group. Patients suffering from laryngitis, catarrhal rhinopharyngitis and sinusitis noted markedly rapid improvement. The
physicians' assessments of efficacy of treatment were excellent or good for 97.3% of patients treated with SP compared with only 21.9% of those
treated with placebo. In a similar study of chronic bronchitis, conducted by a team of otolaryngolosits, the SP-treated group showed excellent
results compared with the placebo group in the improvement of loosening sputum, frequency of cough and expectoration. Other improvements
included the posterior nasal hydro rhea and rhinos enosis. The administration of SP reduces the viscosity of the nasal mucus to a level at which
maximal transport can be achieved. It has also been demonstrated that the simultaneous use of the peptidase and an antibiotic results in
increased concentrations of the antibiotic at the site of the infection.
The mechanisms of action of SP, at the sites of various inflammatory processes consist fundamentally of a reduction of the exudative phenomena
and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinose aggregates and reduces the
viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process.
Studies suggest that SP has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process. This is
substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonizing protein and reductions in concentrations of
haptoglobulin, which is a scavenger protein that inhibits lysosomal protease.
Carpal tunnel syndrome is a form of musculol-igamentous strain caused by repetitive motion injury. Individuals who work at keyboard terminals are
particularly susceptible to this condition. While surgery has been considered the first line treatment for carpal tunnel syndrome, recent studies
reveal that the use of anti-inflammatory enzymes (e.g. SP and bromelain) in conjunction with vitamins B2 and B6 are also effective. The use of
non-invasive, nutritional approaches to the treatment of this common condition will become more important as a generation of keyboard operators
approach retirement. Several research groups have reported the intestinal absorption of SP. SP is well absorbed orally when formulated with an
enteric coating. It is known that proteases and peptidases are only absorbed in the intestinal area. These enzymes are mobilized directly to the
blood and are not easily detectible in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal
tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine
in a biologically and immunologically active form.
Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. SP), such as repression of
oedema and repression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikrein-kinin system
and the complement system, thus modifying the inflammatory response. In vitro and in vivo studies reveal that SP has a specific, anti-inflammatory
effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large
patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory
agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as SP would be a welcome addition to the
physician's armamentarium of physiologic agents.
The simple answer is serrapeptase is the best anti-inflammatory enzyme available. It does NOT affect any drugs whatsoever except that it may
make them unnecessary.
Serraezyme by Good Health USA